Artificial saliva protects teeth from acid and decay
The key ingredient, CANECPI-5, binds directly to enamel, forming a shield against acids.
Scientists have created an artificial saliva using a sugarcane protein that can protect teeth and fight bacteria. The key ingredient, CANECPI-5, binds directly to enamel, forming a shield against acids that cause decay.
Early tests show it works even better when paired with fluoride and xylitol, significantly reducing damage to teeth. The innovation could be especially life-changing for cancer patients who lose saliva production after treatment.
Researchers at the Bauru School of Dentistry, University of São Paulo, found that CANECPI-5 creates a protective ‘shield’ over teeth. This layer helps defend enamel from acids found in beverages such as juice and alcohol, as well as acids from the stomach.
The findings were published in the Journal of Dentistry.
Professor Marília Afonso Rabelo Buzalaf, lead author, said: “We tested the mouthwash developed with CANECPI-5 by applying this solution to small pieces of animal teeth once a day for one minute. Based on these results, we’ll conduct further research so that we can think about applications of this product.
“This is the first product that uses the concept of acquired pellicle [a thin protective layer that quickly forms on the tooth surface] to treat xerostomia, which is the sensation of a dry mouth caused by a lack of saliva. We use substances that will reformulate the composition of the proteins that bind to the teeth.
“We’ve developed a process in which CANECPI-5 binds directly to tooth enamel, helping to make teeth more resistant to the action of acids produced by bacteria.”
The study showed that CANECPI-5 works best when combined with fluoride and xylitol. In testing, the artificial saliva spray reduced bacterial activity and slowed tooth demineralisation.
The development is especially important because there is currently no dedicated product available to treat the severe cavities that often occur after radiation therapy for head and neck cancer.